Tottenham missed a rare chance to go top of the Premier League on Wednesday when West Ham won their London derby 1-0 to go within a point of the four Champions League places.
Spurs remain three points behind leaders Leicester City following the 1-0 set-back at West Ham United but remain favourites to win the title among many bookmakers and pundits.
Michail Antonio's seventh-minute header from Dimitri Payet's corner was the only goal of the game but West Ham dominated the encounter, pressing the visitors in a style similar to the one that Spurs have employed to such good effect this season.
"Was it nerves? No. We made some mistakes that normally we don't make", Potchettino said in The Independent.
"It [the clash with Arsenal] is very tough - it's another big derby for us but we're looking forward to it. We've been good at home in recent times so we've got to keep playing the way we are and try to get three points". We are very disappointed.
James Collins is the latest casualty after suffering a hamstring injury, while Angelo Ogbonna had his ankle heavily strapped after limping through the second half. Second half, we tried to play, create chances and manage the game.
First, give them a day off when we can, so we make them clear and happy before the next day's training.
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Pedro Obiang replaced Sam Byram as the Hammers went 3-5-2 and frustrated Spurs throughout the first-half while threatening on the break and pinching an early goal at the other end.
In footballing terms, Spurs absolutely played Swansea off the park on Sunday, taking 34 shots with 14 of them on target.
The ESPN FC boys assess which team has the better squad, Tottenham or Arsenal, and deliver their predictions for the weekend. All we can do is use it as motivation and hope to get something out of the next game.
Pochettino said: "A missed opportunity, but in football you need to play first".
It is especially incredible considering that Pochettino has more often than not fielded his best team in all competitions, including the FA Cup and the Europa League, a competition largely ignored by his predecessors.
And the talented teenager insists he's the top dog when Mauricio Pochettino's squad are able to enjoy some downtime in front of a games console.