Spurs head coach Gregg Popovich said there's "not really" a minutes restriction on Ginobili, who has out for the team's last 12 games.
The Kings, who had vowed they would fight for a playoff berth, lacked the fight to bounce back against San Antonio, which improved to 30-0 at home despite the absence of three starters.
Timberwolves 132, Nets 118 - Karl-Anthony Towns had 28 points, 7 assists, and 6 rebounds and host Minnesota shot a franchise-record 68.4 percent from the field in beating Brooklyn.
In his radio show, Kings commentator Grant Napear said that if the Kings were to win this game they needed to be on their A-game while the Spurs were on an off night.
Kyrie Irving added 21 points and Iman Shumpert busted out of a shooting slump to add 12 points and a career-high 16 rebounds for Cleveland, which moved 2 1/2 games ahead of Toronto for the best record in the Eastern Conference.
Sacramento Kings forward Rudy Gay dunks during the first half of an NBA basketball game against the San Antonio Spurs, Saturday, March 5, 2016, in San Antonio. "It's been a while I think since we did that good on the road trip; not even just the wins, but the way we played defensively and stuff like that". C Kostas Koufos missed the game with food poisoning....
Mar 5, 2016; San Antonio, TX, USA; San Antonio Spurs shooting guard Manu Ginobili (20) celebrates wi ...
Evidence of Zika's risk to pregnant women continues to grow
This year's case comes as the state fights an outbreak of mosquito-borne dengue fever, with 260 cases reported on the Big Island. Researchers at Johns Hopkins said they have found a new biological link between the Zika virus and microcephaly in babies.
Spurs: San Antonio has the fourth-longest home winning streak in league history, breaking a tie with the 1985-86 Boston Celtics. A Rondo buzzer-beater three brought the Kings within 57-54 at halftime as the Kings defense became more active, but the three-point deficit at the break was the closest Sacramento would get.
"There have been a lot of teams disappointed on this court", he said. "I can't say much more about it, but I heard it. It wasn't that I was so focused I couldn't hear it. It makes me feel good and give you a boost, too".
If it wasn't for the historic run of the Golden State Warriors, they would be the talk of the National Basketball Association and the odds on favorite to win it all.
The Kings next matchup will be in "The Big Easy" as they play the New Orleans Pelicans on Monday. The injury required surgery, which Ginobili underwent in the early morning hours of February 5 following the Spurs' victory over the Pelicans on February 4.
"Not at all", Ginobili said.
There are some highlights that start about 30 seconds into this interview, which also features Ginobili joking that he should only be taken off the shelf once a month.
Meanwhile, the Kings have lost four of their last five and badly need to turn things around if they are going to be in with a shot at making the finals come the pivotal last 10 games of the season.