Kesha's name has been in the news in recent weeks because of her court battle with music producer Dr. Luke, who she says drugged and sexually abused her and who would not release her from her contractual duties with his company.
"To come back after so long away and be so warmly received is really lovely - thank you so much", said Adele, dressed in a floor-length red gown, as she picked up her first award of the night for best British female.
She added: 'I want to thank my manager, Jonathan Dickens, and I want to thank my boyfriend for supporting me. She told her fans that she was never sure of making a comeback and thanked everyone for being so nice to her and for providing support. The British rapper Stormzy, one of whose titles was ranked top 10 of United Kingdom sales past year, said he was disappointed not to see her represented musical family.
Meanwhile, British boyband One Direction beat Adele in the category of British Artist Video of the Year, which is fan-voted.
Adele closed the show with a moving performance of When We Were Young.
James Bay, who won British Male Solo Artist (which was presented by Kylie Minogue), teamed up with Justin Bieber, to play guitar while he sang his track Love Yourself.
California wrestler urges tournament delay after contracting 'mat herpes'
The virus has been known to infect wrestlers throughout the country over the years. According to Rick, Independence High lacked this type of safety practice.
Liam Payne and Louis Tomlinson accepted the award and earlier joked that if they won they would sell Harry Styles and Niall Horan's statuettes.
James Bay receives his Best British Male Solo Artist award from Kylie Minogue on stage during the 2016 Brit Awards at the O2 Arena, London.
Coldplay, who opened the show with Hymn For The Weekend and won the award for British group, are at number five.
Adele cries as she accepts the award for Global Success onstage at the Brit Awards on Wednesday. Alexis Petridis, rock critic for The Guardian, he has accused the Brits to "make the British pop music more boring than it is". "David Bowie is deeply embedded in the heart of British culture, as a fixture within our collective inner psyche".
Her four-award haul is the most wins for any individual act since 1995, when Blur took home four Brit Awards, reported BBC. Members of his band from throughout his four-and-a-half decades of performances took to the stage to perform a medley of his best-loved songs, ultimately joined by singer Lorde, who brought the emotional performance to an end with Bowie's "Life on Mars".