Comedian Garry Shandling died Thursday at the age of 66 after he was rushed to the hospital from his Los Angeles home following a medical emergency, according to to Los Angeles officials.

The Chicago-born Shandling moved from a short stint in the advertising business to comedy writing and standup. He also appeared in an episode of Jerry Seinfeld's Comedians in Cars Getting Coffee in January, titled, "It's Great That Garry Shandling Is Still Alive".

In 1992 Shandling essentially re-invented the sitcom again with The Larry Sanders Show, this time a series set behind the scenes of a fictional talk show that drew heavily on his experiences as a guest host on The Tonight Show. The HBO sitcom earned 56 Emmy nominations throughout its six-year run. Written and directed by David Duchovny, a close friend of Shandling, the episode sees the late star playing a fictionalized Garry Shandling who has been cast as Agent Fox Mulder in a Hollywood production of a feature film based on an X-File.

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His cause of death is now unknown.

Some may only know of him from his appearance in the Marvel Cinematic Universe as U.S. Senator and HYDRA member Stern, but if that is the extent of your knowledge on Shandling's life and career, then you've been missing out and should start catching up on his other work.

Not long after It's Garry Shandling's Show ended, Shandling began developing what would become another cable classic.