Tottenham's other goals were scored by Harry Kane, who also missed a penalty, and substitute Son Heung-min.
Harry Kane made it 2-1 from a corner seven minutes into the second half and the Saints were reduced to 10 men soon after when Nathan Redmond was sent off for impeding Alli in the box.
With December wrapping up in a couple of days, three Tottenham players that make up a portion of the team's spine spoke with Spurs TV following a well-deserved 4-1 win yesterday evening.
Tottenham manager Mauricio Pochettino says he does not expect the club to do any business in the January transfer window.
In what has been a great year for Tottenham, which has seen them record their best ever Premier League finish, we thought we'd take a look back at their 2016, and have thus identified their top THREE games of the year...
Spurs have now won five out of their last six matches with the latest victory coming against Southampton and Kane reckons the ten-day break ahead of the Christmas schedule has done them good.
"A lot of people would think that", he said.
"There was pressure on us to win and it's a hard place to come", Kane told Tottenham's official club website.
Late block saves Bulldogs' bowl victory
Defensively, the Bulldogs are yielding 33.1 points and 455.9 total yards (283.1 in passing and 178.2 in rushing) per game. Miami held the football for 10:16 longer than the Bulldogs, keeping Peter Sirmons' defense on the field a long time.
However, the Belgian global now looks to be back to full fitness and is expected to replace Jan Vertonghen in the back four on Sunday with his compatriot ruled out of the game due to suspension.
"I think it's impossible to keep the same level he was playing at, which was very high, for the whole season".
The centre-back was booked for dissent in the dying moments, his fifth yellow card of the season, earning him a suspension for the match away to Watford on Sunday.
"Toby Alderweireld picked up a virus the day before Southampton".
Southampton remained eighth on 24 points.
"After the red card, the game finished", he told Sky Sports.
Wimmer, 24, has made just two Premier League starts this season and the Austria worldwide has frequently been left out of Pochettino's matchday squads. "It was the end for us".